Research Scientist: Nephrotoxicity & 3D Kidney Modeling

Company Description
DLOC Biosystems is a biotech contract research organization (CRO) that offers preclinical trials on drugs developed by pharma companies using state-of-the-art organ-on-chip technology. It takes $2.6B and 12 years to develop one successful drug because 90% of drugs fail at the late and expensive clinical trial stages. The reason is that preclinical results do not determine the clinical trial failures because tissues grown in the lab do not resemble the tissues in the body. As a solution, DLOC’s organ-on-chip technology focuses on providing the most accurate drug testing services by growing the most in-body mimetic organ models on-chip.

DLOC’s innovative technology has the potential to make drug discovery 50% safer and 40% faster & cheaper. DLOC is achieving this aim by creating patented organ-on-chip devices, automated operating systems, and AIpowered real-time control & data analytics. The devices can grow tissues with microenvironments that resemble the in vivo human tissues, where drugs can be tested, and their therapeutic index can be better predicted.

Role Description and Key Activities
• Conduct experiments to model an organ-on-chip kidney model to test drug-induced nephrotoxicity.
• Provide day-to-day management of the lab
• Carry out standard molecular biology and biochemistry methods with minimal supervision.
• Assist in identifying and characterizing experimental models under the guidance of experienced research staff using organ-on-chip devices with minimal supervision.
• Analyse data of experimental data collected by themselves.
• Provide guidance and supervise the work tasks of less experienced colleagues.
• Prepare the suitable health & safety documents and ensure they’re in place before work commences.
• Ensure the forward planning and coordination of research technical support in their specialist areas. Discuss requirements with the research technical team & be active in liaison with senior management.
• Work in accordance with HSE guidance relating to the use of human tissue (HTA), developing, reviewing, and updating Standard Operating Procedures, COSHH, Safe Systems of Work documents, and risk assessments relevant to their role and in accordance with instruction or training received.
• Work as a member of a broader Team to fulfill duties commensurate with the post’s grade & nature.
• Maintain and actively pursue continual professional development.

This document outlines the duties required at the current time to indicate the level of responsibility. It is not a comprehensive or exhaustive list and may vary to include other reasonable requests.

Essential Qualifications
• Hold a Ph.D. in molecular biology, toxicology, or relevant field. Equivalent experience is considered.
• Experience in working with cell culture, preferably with kidney models.
• Experience in working in an environment with laboratory-based research
• Experience in collaborative working in a relevant environment to achieve team objectives.
• Ability to work using own initiative and to resolve day-to-day issues.
• Excellent organisational skills and the ability to prioritise to deliver high-quality output to deadlines.
• Clear written and oral communication skills. Experienced in health and safety procedures, including COSHH, and contributing to risk assessments within a life science laboratory environment.


Desired Qualifications
• Detailed and extensive knowledge of theory and practice related to the areas of skills relevant to the project (organ-on-chip devices, cell culture, toxicology studies, nephrology)
• Good knowledge and understanding of GLP standards.

You can apply by sending an email with your CV & cover letter in one PDF to

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