Research Scientist: Nephrotoxicity & 3D Kidney modelling

DLOC Biosystems

DLOC Biosystems is a biotech contract research organization (CRO) that offers preclinical trials on drugs developed by pharma companies using state-of-the-art organ-on-chip technology. It takes $2.6B and 12 years to develop one successful drug because 90% of drugs fail at the late and expensive clinical trial stages. The reason is that preclinical results do not determine the clinical trial failures because tissues grown in the lab do not resemble the tissues in the body. As a solution, DLOC’s organ-on-chip technology focuses on providing the most accurate drug testing services by growing the most in-body mimetic organ models on-chip.

DLOC’s innovative technology has the potential to make drug discovery 50% safer and 40% faster and cheaper. The start-up is achieving this aim by creating patented organ-on-chip devices, automated operating systems, and AI-powered real-time control and data analytics. The devices can grow tissues with microenvironments that resemble the in vivo human tissues, where drugs can be tested, and their therapeutic index can be better predicted.


Role description

The key activities that you will carry out during the job are:

  • To conduct experiments to model an organ-on-chip kidney model to test drug-induced nephrotoxicity.
  • To provide day-to-day management of the lab
  • Carry out standard molecular biology and biochemistry methods or adaptations of standard methods as guided by experienced research staff with minimal or no supervision.
  • To assist in identifying and characterizing experimental models under the guidance of experienced research staff using organ-on-chip devices with minimal supervision.
  • Data analysis of experimental data collected by themselves.
  • Provide guidance and supervise the work tasks of less experienced colleagues, assisting with their development to support achieving their objectives.
  • To ensure that appropriate health and safety documentation is in place before work commences and to contribute to preparing those documents where applicable.
  • To ensure the forward planning and coordination of research technical support in their specialist areas. This includes discussing requirements with the research technical team and being proactive in liaison with senior management.
  • To work in accordance with HSE guidance relating to the use of human tissue (HTA), developing, reviewing, and updating Standard Operating Procedures, COSHH, Safe Systems of Work documents, and risk assessments relevant to their role and in accordance with instruction or training received.
  • Work as a member of a broader Team to fulfill duties commensurate with the grade and nature of the post.
  • Maintain and actively pursue continual professional development.

This document outlines the duties required at the current time to indicate the level of responsibility. It is not a comprehensive or exhaustive list and may vary to include other reasonable requests.


Required Qualifications

Essential Skills

  • Hold a Ph.D. in molecular biology, toxicology, or relevant field. Equivalent recognized qualifications or experience will be considered.
  • Experience in working with cell culture, preferably with kidney models.
  • Experience in working in an environment with laboratory-based research
  • Experience in collaborative working in a relevant environment to achieve team objectives.
  • Ability to work using own initiative and to resolve day-to-day issues.
  • Excellent organisational skills and the ability to prioritise to deliver high-quality output to deadlines.
  • Clear written and oral communication skills. Experienced in health and safety procedures, including COSHH, and contributing to risk assessments within a life science laboratory environment.

Desired skills

  • Detailed and extensive knowledge of theory and practice related to the areas of skills relevant to the project (organ-on-chip devices, cell culture, toxicology studies, nephrology)
  • Good knowledge and understanding of GLP standards.

If you think this job suits your career vision, please consider applying.

Please attach a cover letter to your CV in 1 PDF and email:

Only shortlisted candidates will be contacted.

We look forward to hearing from you!

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