York Bioanalytical Solutions is the premier, independent UK-based provider of bioanalytical, metabolism and ADME services to the world’s pharmaceutical industry. As such, we have strong ideas about the value of our staff in providing a top quality scientific service to our clients and recognise the importance of providing an environment in which our employees feel valued and can develop to the best of their abilities.

Following significant expansion of our DMPK section, we require an experienced scientist to join our friendly, professional team. The successful candidate will play a leading role in the delivery of metabolite characterisation studies in support of human or animal health drug discovery and development, at our facility at Discovery Park in Sandwich, Kent.

 

The ideal candidate will have:
• In-depth knowledge of metabolite characterisation strategies across drug discovery and development
• Significant expertise in the application of relevant analytical tools to metabolite characterisation studies, including HPLC, radiochemical
detection, UV and mass spectrometry (both nominal mass and high-resolution)
• Detailed understanding of metabolism and enzymology and their significance to drug discovery and drug development programs
• Ability to design and perform iterative metabolism experiments and troubleshoot analytical issues
• Ability to train others to perform all aspects of metabolite characterisation studies
• Flexibility to undertake multiple, potentially complex studies in parallel
• Aptitude for scientific publications, presentations and customer interactions
• A meticulous approach to record keeping and report preparation

 

Candidates will ideally be educated to degree or higher degree level in a relevant scientific subject. At least 5 years’ experience of work in a metabolite characterisation role is essential. The grading of the role is flexible dependent on experience and relevant qualifications

 

If you would like to work in a friendly and flexible environment and feel you have the right qualities, please send a detailed CV to:

Angus Nedderman, York Bioanalytical Solutions, Discovery Park House, Discovery Park, Ramsgate Road, Sandwich, Kent, CT13 9ND

angus.nedderman@yorkbio.com; www.yorkbio.com

 

Company Description
DLOC Biosystems is a biotech contract research organization (CRO) that offers preclinical trials on drugs developed by pharma companies using state-of-the-art organ-on-chip technology. It takes $2.6B and 12 years to develop one successful drug because 90% of drugs fail at the late and expensive clinical trial stages. The reason is that preclinical results do not determine the clinical trial failures because tissues grown in the lab do not resemble the tissues in the body. As a solution, DLOC’s organ-on-chip technology focuses on providing the most accurate drug testing services by growing the most in-body mimetic organ models on-chip.

DLOC’s innovative technology has the potential to make drug discovery 50% safer and 40% faster & cheaper. DLOC is achieving this aim by creating patented organ-on-chip devices, automated operating systems, and AIpowered real-time control & data analytics. The devices can grow tissues with microenvironments that resemble the in vivo human tissues, where drugs can be tested, and their therapeutic index can be better predicted.

Role Description and Key Activities
• Conduct experiments to model an organ-on-chip kidney model to test drug-induced nephrotoxicity.
• Provide day-to-day management of the lab
• Carry out standard molecular biology and biochemistry methods with minimal supervision.
• Assist in identifying and characterizing experimental models under the guidance of experienced research staff using organ-on-chip devices with minimal supervision.
• Analyse data of experimental data collected by themselves.
• Provide guidance and supervise the work tasks of less experienced colleagues.
• Prepare the suitable health & safety documents and ensure they’re in place before work commences.
• Ensure the forward planning and coordination of research technical support in their specialist areas. Discuss requirements with the research technical team & be active in liaison with senior management.
• Work in accordance with HSE guidance relating to the use of human tissue (HTA), developing, reviewing, and updating Standard Operating Procedures, COSHH, Safe Systems of Work documents, and risk assessments relevant to their role and in accordance with instruction or training received.
• Work as a member of a broader Team to fulfill duties commensurate with the post’s grade & nature.
• Maintain and actively pursue continual professional development.

This document outlines the duties required at the current time to indicate the level of responsibility. It is not a comprehensive or exhaustive list and may vary to include other reasonable requests.

Essential Qualifications
• Hold a Ph.D. in molecular biology, toxicology, or relevant field. Equivalent experience is considered.
• Experience in working with cell culture, preferably with kidney models.
• Experience in working in an environment with laboratory-based research
• Experience in collaborative working in a relevant environment to achieve team objectives.
• Ability to work using own initiative and to resolve day-to-day issues.
• Excellent organisational skills and the ability to prioritise to deliver high-quality output to deadlines.
• Clear written and oral communication skills. Experienced in health and safety procedures, including COSHH, and contributing to risk assessments within a life science laboratory environment.

 

Desired Qualifications
• Detailed and extensive knowledge of theory and practice related to the areas of skills relevant to the project (organ-on-chip devices, cell culture, toxicology studies, nephrology)
• Good knowledge and understanding of GLP standards.

You can apply by sending an email with your CV & cover letter in one PDF to wadah@dlocbiosystems.com